Vera C L, Lewin M G, Kase J C, Calderon M D
J Neurosurg. 1975 Aug;43(2):181-91. doi: 10.3171/jns.1975.43.2.0181.
A left facial-spinal-accessory anastomosis was performed for peripheral facial paralysis in an 8-year-old boy. By the fourth postoperative year, the corneal reflex showed a normal latency, and left arm and face movements could be executed independently. The possibility of neural plasticity playing a role in establishing new central relationships which enable the achievement of a "normal" latency corneal reflex and independent face and arm movements is discussed. The latency of the corneal reflex recorded as electrical response of the orbicularis oculi muscle to electrical stimulation of the ipsilateral cornea was measured in normal cats and cats which had undergone a facial-hypoglossal anastomosis 12 to 14 months previously. The latency of the reflex was 8 to 22 msec in normal animals and 200 to 300 msec in the operated cats, while conduction times in the regenerated hypoglossal nerve fibers were found to be within normal limits. This suggests that the long latency of the corneal reflex following the cross anastomosis is due to the time required for transmission across newly-formed connections between the trigeminal terminals and the hypoglossal neurons.
为一名8岁男孩的周围性面瘫实施了左侧面-脊髓-副神经吻合术。术后第四年，角膜反射潜伏期正常，左臂和面部运动可独立进行。文中讨论了神经可塑性在建立新的中枢联系中发挥作用的可能性，这种新联系使得能够实现“正常”的角膜反射潜伏期以及面部和手臂的独立运动。对正常猫和12至14个月前接受过面-舌下神经吻合术的猫，测量了眼轮匝肌对同侧角膜电刺激的电反应所记录的角膜反射潜伏期。正常动物的反射潜伏期为8至22毫秒，手术猫的潜伏期为200至300毫秒，同时发现再生舌下神经纤维的传导时间在正常范围内。这表明交叉吻合术后角膜反射潜伏期延长是由于三叉神经末梢与舌下神经元之间新形成连接的传导需要时间。
