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[新型正电子发射断层显像(PET)示踪剂的分子成像]

[Molecular imaging with new PET tracers].

作者信息

Beer A J, Schwaiger M

机构信息

Klinik und Poliklinik für Nuklearmedizin, Klinikum rechts der Isar der Technischen Universität München.

出版信息

Radiologe. 2007 Jan;47(1):8-17. doi: 10.1007/s00117-006-1448-6.

Abstract

In the recent years, positron emission tomography (PET) has gained more and more importance, especially in oncology for primary staging, as well as for response evaluation. The glucose analogon (18)F-FDG is the most widely used tracer up to now. In this paper, we review the applications of newly developed, more specific PET tracers. These tracers allow for imaging of a variety of biological processes, such as hypoxia and proliferation. The expression of different receptors can be visualized, like the somatostatin receptor 2 and the integrin alphavbeta3. Moreover, gene expression can be imaged as well. While most of these approaches are currently in the first phases of clinical evaluation, imaging of hypoxia and proliferation might be integrated into the daily routine in the near future.

摘要

近年来,正电子发射断层扫描(PET)的重要性日益凸显,尤其是在肿瘤学的初始分期以及疗效评估方面。葡萄糖类似物(18)F-FDG是目前应用最为广泛的示踪剂。在本文中,我们回顾了新开发的、更具特异性的PET示踪剂的应用。这些示踪剂能够对多种生物学过程进行成像,如缺氧和增殖。不同受体的表达也能够可视化,例如生长抑素受体2和整合素αvβ3。此外,基因表达同样可以成像。虽然目前这些方法大多处于临床评估的第一阶段,但缺氧和增殖成像在不久的将来可能会纳入日常临床实践。

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