Berthold L D, Haras G, Mann M, Alzen G
Kinderradiologie, Zentrum für Radiologie, Universitätsklinikum Giessen und Marburg GmbH, Standort Giessen.
Rofo. 2006 Dec;178(12):1235-42. doi: 10.1055/s-2006-927151.
The aim of this study was to assess bone density values in the trabecular substance of the lumbar vertebral column in children and young adults in Germany from infancy to the age of peak bone mass.
We performed quantitative computed tomography (QCT) on the first lumbar vertebra in 28 children and adolescents without diseases that may influence bone metabolism (15 boys, 13 girls, mean ages 11 and 8 years, respectively). We also measured 17 healthy young adults (9 men, 8 women, mean ages 20 and 21 years). We used a Somatom Balance Scanner (Siemens, Erlangen) and the Siemens Osteo software. Scan parameters: Slice thickness 1 cm, 80 kV, 81 or 114 mAs. We measured the trabecular bone density and the area and height of the vertebra and calculated the volume and content of calcium hydroxyapatite (Ca-HA) in the trabecular substance of the first lumbar vertebra.
Prepubertal boys had a mean bone density of 148.5 (median [med] 150.1, standard deviation [SD] 15.4) mg/Ca-HA per ml bone, and prepubertal girls had a mean density of 149.5 (med 150.8, SD 23.5) mg/ml. We did not observe a difference between prepubertal boys and girls. After puberty there was a significant difference (p < 0.001) between males and females: Mean density (male) 158.0, med 162.5, SD 24.0 mg/ml, mean density (female) 191.2, med 191.3, SD 17.7 mg/ml. The Ca-HA content in the trabecular bone of the first lumbar vertebra was 1.1 (med 1.1, SD 0.5) g for prepubertal boys and 1.1 (0.9, 0.4) g for prepubertal girls. For post-pubertal males, the mean Ca-HA content was 3.5 g, med 3.5, SD 0.5 g, and for post-pubertal females, the mean content was 2.8, med 2.7, SD 0.4 g.
The normal trabecular bone mineral density is 150 mg/ml with a standard deviation of 20 mg/ml independent of age or gender until the beginning of puberty. Peak bone mass (bone mineral content) in the trabecular substance of the lumbar vertebral column is higher in males than in females, and peak bone density is higher in young female adults than in young male adults.
本研究旨在评估德国从婴儿期到骨量峰值年龄的儿童和年轻成年人腰椎小梁骨的骨密度值。
我们对28名无可能影响骨代谢疾病的儿童和青少年（15名男孩，13名女孩，平均年龄分别为11岁和8岁）的第一腰椎进行了定量计算机断层扫描（QCT）。我们还测量了17名健康的年轻成年人（9名男性，8名女性，平均年龄分别为20岁和21岁）。我们使用了Somatom Balance扫描仪（西门子，埃尔朗根）和西门子骨软件。扫描参数：层厚1cm，80kV，81或114mAs。我们测量了小梁骨密度、椎体的面积和高度，并计算了第一腰椎小梁骨中羟基磷灰石钙（Ca-HA）的体积和含量。
青春期前男孩的平均骨密度为每毫升骨148.5（中位数[med]150.1，标准差[SD]15.4）mg/Ca-HA，青春期前女孩的平均密度为149.5（med 150.8，SD 23.5）mg/ml。我们未观察到青春期前男孩和女孩之间存在差异。青春期后，男性和女性之间存在显著差异（p<0.001）：平均密度（男性）158.0，med 162.5，SD 24.0mg/ml，平均密度（女性）191.2，med 191.3，SD 17.7mg/ml。第一腰椎小梁骨中的Ca-HA含量，青春期前男孩为1.1（med 1.1，SD 0.5）g，青春期前女孩为1.1（0.9，0.4）g。青春期后男性的平均Ca-HA含量为3.5g，med 3.5，SD 0.5g，青春期后女性的平均含量为2.8，med 2.7，SD 0.4g。
在青春期开始之前，正常小梁骨矿物质密度为150mg/ml，标准差为20mg/ml，与年龄或性别无关。腰椎小梁骨的峰值骨量（骨矿物质含量）男性高于女性，而年轻女性成年人的峰值骨密度高于年轻男性成年人。
