Lu P W, Briody J N, Ogle G D, Morley K, Humphries I R, Allen J, Howman-Giles R, Sillence D, Cowell C T
Robert Vines Growth Research Centre, Royal Alexandra Hospital for Children, Sydney, New South Wales, Australia.
J Bone Miner Res. 1994 Sep;9(9):1451-8. doi: 10.1002/jbmr.5650090918.
Bone mineral density (BMD) of total body (TBMD), lumbar spine (L2-4), and femoral neck was measured in 266 normal subjects (136 males) aged 4-27 years (mean 13 years) using dual-energy x-ray absorptiometry (DXA). BMD of all sites increased significantly with age until 17.5 years in males and 15.8 years in females, except for femoral neck BMD in females, which peaked at age 14.1 years. Males had higher peak TBMD, which was attributed to greater weight and lean tissue mass. In contrast, despite a later timing, peak L2-4 BMD in males was not different from that in females. Before peak BMD, weight was the best predictor of TBMD and L2-4 BMD in both sexes (r2 ranged from 0.77 to 0.88), whereas femoral neck BMD was predicted equally by height and weight. Longitudinal information collected from 53 (25 boys) of these children, aged 4-16.9 years, showed that the average annualized gain in TBMD was 0.047 g/cm2 for boys and 0.039 g/cm2 for girls. No significant difference in the association between age and BMD (slopes) was found between cross-sectional and longitudinal data for either sex. We conclude that the timing for peak BMD was consistent for total body, lumbar spine, and femoral neck for each sex. The earlier peak BMD in females is most likely related to earlier puberty. The cross-sectional normative data of this study are useful in serving as a standard for serial assessment in health and disease states.
采用双能X线吸收法（DXA）对266名年龄在4至27岁（平均13岁）的正常受试者（136名男性）进行全身骨矿物质密度（TBMD）、腰椎（L2 - 4）和股骨颈骨密度测量。所有部位的骨密度在男性17.5岁、女性15.8岁之前随年龄显著增加，但女性股骨颈骨密度在14.1岁时达到峰值。男性的峰值TBMD较高，这归因于体重和瘦组织量更大。相比之下，尽管男性L2 - 4骨密度峰值出现较晚，但与女性并无差异。在骨密度峰值出现之前，体重是男女TBMD和L2 - 4骨密度的最佳预测指标（r2范围为0.77至0.88），而股骨颈骨密度由身高和体重同等预测。从这些年龄在4至16.9岁的儿童中选取53名（25名男孩）收集的纵向信息显示，男孩TBMD的年均增加量为0.047g/cm2，女孩为0.039g/cm2。男女的横断面数据和纵向数据在年龄与骨密度关联（斜率）方面均未发现显著差异。我们得出结论，男女全身、腰椎和股骨颈的骨密度峰值出现时间是一致的。女性较早的骨密度峰值很可能与青春期较早有关。本研究的横断面规范数据有助于作为健康和疾病状态下系列评估的标准。
