Dubinsky B, Kinnard W J, Buckley J P
J Pharm Sci. 1975 Oct;64(10):1647-51. doi: 10.1002/jps.2600641012.
Minimally effective oral doses of chlorpromazine, imipramine, and pentobarbital necessary to block a discrete trial (bar-press) conditioned avoidance response were compared in cats chronically implanted with electrodes over the cerebral cortex and in the nucleus centralis medialis of the thalamus. Three conditioned stimulus contingencies consisting of tone and low or high voltage thalamic stimulation were presented. Minimal conditioned response blocking doses of these agents produced only slight qualitative changes in cortically recorded recruitment. Drug treatment affected the conditioned stimulus contingencies differentially, and the rank order in terms of ease of disruption of the conditioned avoidance response was high voltage thalamic conditioned stimulus greater than low voltage thalamic conditioned stimulus greater than auditory conditioned stimulus. The differential effect of these drugs might have been due to the additive inhibition of these agents and the thalamic conditioned stimulus on performance. With the exception of chlorpromazine, the behavioral effects of these drugs and their effects on recruitment were dissociated.
在长期将电极植入大脑皮层和丘脑内侧中央核的猫中，比较了阻断离散试验（压杆）条件性回避反应所需的氯丙嗪、丙咪嗪和戊巴比妥的最低有效口服剂量。呈现了由音调以及低电压或高电压丘脑刺激组成的三种条件刺激意外情况。这些药物的最低条件反应阻断剂量仅在皮层记录的募集方面产生了轻微的质性变化。药物治疗对条件刺激意外情况的影响存在差异，就破坏条件性回避反应的难易程度而言，其顺序为高电压丘脑条件刺激大于低电压丘脑条件刺激大于听觉条件刺激。这些药物的差异效应可能是由于这些药物和丘脑条件刺激对行为表现的累加抑制作用。除氯丙嗪外，这些药物的行为效应与其对募集的效应是分离的。
