Raeva S, Lukashev A, Lashin A
Laboratory of Human Cell Neurophysiology, Institute of Chemical Physics, U.S.S.R. Academy of Sciences, Moscow.
Electroencephalogr Clin Neurophysiol. 1991 Aug;79(2):133-40. doi: 10.1016/0013-4694(91)90051-5.
Microelectrode recording was carried out in the thalamic reticularis nucleus (Rt) during 51 stereotaxic operations performed in locally anesthetized dyskinetic patients. The spontaneous activity (SA) of 426 units was studied by means of computer processing techniques. Three types of unit (A, B, C) were shown to exist in Rt: with irregular low-frequency (0-10/sec) discharges (A type, 51%); bursting in short trains (10-30 msec) with unstable rhythmic pattern (2-5/sec; B type, 42%); presenting long duration (0.1-2 sec) high frequency bursts and relatively constant interburst silences (80-150 msec; C type, 7%). During short-term anesthesia A unit discharges disappeared; on the contrary the rhythmic bursts of B neurons were synchronized and presented a more stable frequency. The 3 types of cell were present in the whole Rt. However, a number of discharge characteristics (frequency, variation of rhythm) of A and B units changed significantly with the position of the cells in the Rt. No relationship was found between the frequencies of the rhythmic bursts and the parkinsonian tremor. With the use of a multiparametric statistical procedure, a relation was, however, found between the intensity of the peripheral tremor and the stability of the average frequency of the B type rhythmic bursts. The possible origins of rhythmic bursts of B and C neurons are discussed.
在对局部麻醉的运动障碍患者进行的51次立体定向手术过程中，对丘脑网状核（Rt）进行了微电极记录。借助计算机处理技术研究了426个单位的自发活动（SA）。结果显示Rt中存在三种类型的单位（A、B、C）：具有不规则低频（0 - 10/秒）放电（A类，51%）；以短串（10 - 30毫秒）爆发，节律模式不稳定（2 - 5/秒；B类，42%）；呈现持续时间长（0.1 - 2秒）的高频爆发以及相对恒定的爆发间期沉默（80 - 150毫秒；C类，7%）。在短期麻醉期间，A单位放电消失；相反，B神经元的节律性爆发同步，且频率更稳定。这三种类型的细胞在整个Rt中均有存在。然而，A和B单位的一些放电特征（频率、节律变化）随细胞在Rt中的位置而显著变化。未发现节律性爆发的频率与帕金森震颤之间存在关联。然而，通过多参数统计程序，发现外周震颤的强度与B型节律性爆发平均频率的稳定性之间存在关联。讨论了B和C神经元节律性爆发的可能起源。
