Raeva S N, Vainberg N A, Dubynin V A
Laboratory of Human Cellular Neurophysiology, Russian Academy of Sciences, Academician N. N. Burdenko Institute of Neurosurgery, Moscow, Russia.
Neurosci Behav Physiol. 1998 Sep-Oct;28(5):513-20. doi: 10.1007/BF02463011.
Background spike activity of 235 cells of the integrative subcortical motor center, i.e., the ventrolateral nucleus of the thalamus, were analyzed in nonanesthetized human brains during stereotaxic surgery in patients with various forms of Parkinson's disease. Previous data on the existence of two major types of neurons with convergent properties in the ventrolateral nucleus were confirmed. These cell types are: 1) cells with irregular occasional activity, with a tendency for spikes to group into the frequency ranges 5 +/- 1 and 10-30 Hz (type A cells, 74%), and 2) cells with constant rhythmic (3-6 Hz) generation of short volleys of discharges, with an interval structure similar to that of low-threshold Ca(2+)-dependent volley activity (type B, 26%). This is the first report demonstrating that changes in the functional state of the brain (after repeated movement trials, in transient anesthesia) are accompanied by transiently occurring transformations of the initial irregular activity of A cells into a rhythmic, volley-like pattern whose interval structure was in some cases similar to the spike activity of B cells. Differences in the localizations of A and B neurons in the ventrolateral nucleus are described, along with differences in the correlation characteristics of their background spike activity with the pathological features of Parkinson's disease (tremor, rigidity). The nature of the two types of convergent neurons in the ventrolateral nucleus is discussed, and a basis is laid for the importance of the functional factor in understanding the transformation of their background spike activity, due to the properties of cell membranes and intercellular and interstructure interactions in conditions of the living nonanesthetized human brain.
在对患有各种形式帕金森病的患者进行立体定向手术期间，对235个整合性皮质下运动中枢（即丘脑腹外侧核）细胞的背景放电活动在未麻醉的人脑中进行了分析。先前关于丘脑腹外侧核中存在两种具有会聚特性的主要神经元类型的数据得到了证实。这些细胞类型为：1）具有不规则偶发活动的细胞，其放电有聚集在5±1和10 - 30Hz频率范围内的趋势（A型细胞，74%），以及2）具有恒定节律性（3 - 6Hz）短串放电产生的细胞，其间隔结构类似于低阈值钙依赖性串放电活动（B型，26%）。这是第一份报告表明，大脑功能状态的变化（在重复运动试验后、在短暂麻醉期间）伴随着A型细胞初始不规则活动的短暂转变，转变为一种节律性、类似串放电的模式，其间隔结构在某些情况下类似于B型细胞的放电活动。描述了A和B神经元在丘脑腹外侧核中的定位差异，以及它们的背景放电活动与帕金森病病理特征（震颤、强直）的相关性特征差异。讨论了丘脑腹外侧核中两种会聚神经元的性质，并为功能因素在理解其背景放电活动转变中的重要性奠定了基础，这是由于在未麻醉的活人脑中细胞膜特性以及细胞间和结构间相互作用所致。
