Buchsbaum Gunhilde M, Duecy Erin E, Kerr Lindsey A, Huang Li-Shan, Perevich MaryAnn, Guzick David S
Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York 14642, USA.
Obstet Gynecol. 2006 Dec;108(6):1388-93. doi: 10.1097/01.AOG.0000245784.31082.ed.
To investigate the role of vaginal delivery and familial factors in the development of pelvic organ prolapse by comparing the prevalence of this condition in nulliparous women and their parous sisters.
Pairs of nulliparous and parous postmenopausal sisters were recruited for assessment of pelvic organ prolapse. One hundred one sister pairs underwent clinical evaluation. Pelvic organ prolapse was recorded using the Pelvic Organ Prolapse Quantification System.
The majority of women had no pelvic organ prolapse. By compartment there was a 74.3% to 91.1% concordance in prolapse stage within sister pairs. In discordant sister pairs, the parous sister was found to have the more advanced prolapse 88% of the time.
High concordance of pelvic organ prolapse in nulliparous and parous sister pairs suggests a familial predisposition toward developing this condition. However, vaginal delivery does appear to confer a risk for more advanced pelvic organ prolapse.
II-2.
通过比较未生育女性及其已生育姐妹盆腔器官脱垂的患病率，探讨经阴道分娩和家族因素在盆腔器官脱垂发生中的作用。
招募未生育和已生育的绝经后姐妹对进行盆腔器官脱垂评估。101对姐妹接受了临床评估。使用盆腔器官脱垂定量系统记录盆腔器官脱垂情况。
大多数女性没有盆腔器官脱垂。按腔室划分，姐妹对中脱垂分期的一致性为74.3%至91.1%。在不一致的姐妹对中，88%的情况下已生育的姐妹脱垂程度更严重。
未生育和已生育姐妹对中盆腔器官脱垂的高度一致性表明该病存在家族易感性。然而，经阴道分娩似乎确实会增加发生更严重盆腔器官脱垂的风险。
II-2。
