Cejtin Helen E, Kalinowski Ann, Bacchetti Peter, Taylor Robert N, Watts D Heather, Kim Seijeoung, Massad L Stewart, Preston-Martin Susan, Anastos Kathryn, Moxley Michael, Minkoff Howard L
John H. Stroger Hospital of Cook County, Chicago, Illinois 60626, and University of California, San Francisco, San Francisco, California, USA.
Obstet Gynecol. 2006 Dec;108(6):1423-31. doi: 10.1097/01.AOG.0000245442.29969.5c.
To characterize ovarian failure and prolonged amenorrhea from other causes in women who are both human immunodeficiency virus (HIV) seropositive and seronegative.
This was a cohort study nested in the Women's Interagency HIV Study, a multicenter U.S. study of HIV infection in women. Prolonged amenorrhea was defined as no vaginal bleeding for at least 1 year. A serum follicle stimulating hormone more than 25 milli-International Units/mL and prolonged amenorrhea were used to define ovarian failure. Logistic regressions, chi2, and t tests were performed to estimate relationships between HIV-infection and cofactors with both ovarian failure and amenorrhea from other causes.
Results were available for 1,431 women (1,139 HIV seropositive and 292 seronegative). More than one half of the HIV positive women with prolonged amenorrhea of at least 1 year did not have ovarian failure. When adjusted for age, HIV seropositive women were about three times more likely than seronegative women to have prolonged amenorrhea without ovarian failure. Body mass index, serum albumin, and parity were all negatively associated with ovarian failure in HIV seropositive women.
HIV serostatus is associated with prolonged amenorrhea. It is difficult to ascertain whether the cause of prolonged amenorrhea is ovarian in HIV-infected women without additional testing.
II-2.
鉴别感染和未感染人类免疫缺陷病毒（HIV）的女性中卵巢功能衰竭及由其他原因导致的长期闭经。
这是一项嵌套于女性机构间HIV研究中的队列研究，该研究是美国一项关于女性HIV感染的多中心研究。长期闭经定义为至少1年无阴道出血。血清促卵泡生成素超过25毫国际单位/毫升及长期闭经用于定义卵巢功能衰竭。采用逻辑回归、卡方检验和t检验来评估HIV感染及其他因素与卵巢功能衰竭和其他原因导致的闭经之间的关系。
1431名女性（1139名HIV血清阳性和292名血清阴性）的结果可用。闭经至少1年的HIV阳性女性中，超过一半没有卵巢功能衰竭。校正年龄后，HIV血清阳性女性出现无卵巢功能衰竭的长期闭经的可能性是血清阴性女性的约三倍。体重指数、血清白蛋白和产次在HIV血清阳性女性中均与卵巢功能衰竭呈负相关。
HIV血清状态与长期闭经有关。在未进行额外检测的情况下，很难确定HIV感染女性长期闭经的原因是否为卵巢因素。
II-2。
