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透析撤机:姑息治疗视角

Withdrawal from dialysis: a palliative care perspective.

作者信息

Chater S, Davison S N, Germain M J, Cohen L M

机构信息

Edinburgh Cancer Center, Western General Hospital, Edinburgh, Scotland, UK.

出版信息

Clin Nephrol. 2006 Nov;66(5):364-72. doi: 10.5414/cnp66364.

Abstract

A retrospective chart review was conducted in this pilot study of 35 patients who withdrew from dialysis and were followed by a palliative care team. Data included etiology of end-stage renal disease, comorbid illnesses, mode of dialysis and duration, survival time after withdrawal, reason for withdrawal, mental competency, symptom management, and the nature of death. Mean survival time was 10 days. The most frequent symptoms following withdrawal were confusion, agitation, pain and dyspnea. 1/3 of the sample were cognitively impaired at the time of the withdrawal decision. 17% experienced suffering during the withdrawal period, 24% had unrelieved symptoms, 19% psychological distress, while just over 1/3 of patients died alone. With the provision of palliative care, symptom prevalence in the last 24 hours dropped from 53 to 20% for pain, 68 to 33% for agitation and 46 to 26% for dyspnea. Opioids and benzodiazepines were used in the treatment of over 90% of patients. Palliative medicine has the potential to improve the care of patients who discontinue dialysis.

摘要

在这项初步研究中,对35例停止透析并由姑息治疗团队随访的患者进行了回顾性病历审查。数据包括终末期肾病的病因、合并症、透析方式和持续时间、停止透析后的生存时间、停止透析的原因、精神状态、症状管理以及死亡性质。平均生存时间为10天。停止透析后最常见的症状是意识模糊、烦躁不安、疼痛和呼吸困难。三分之一的样本在做出停止透析决定时存在认知障碍。17%的患者在停止透析期间遭受痛苦,24%的患者症状未得到缓解,19%的患者存在心理困扰,而略超过三分之一的患者孤独死亡。通过提供姑息治疗,最后24小时内疼痛症状的发生率从53%降至20%,烦躁不安从68%降至33%,呼吸困难从46%降至26%。超过90%的患者使用了阿片类药物和苯二氮䓬类药物进行治疗。姑息医学有潜力改善停止透析患者的护理。

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