Jeremiah Zaccheaus Awortu
Public Health Laboratory, Public Health Division, Ministry of Health, Rivers State, Nigeria.
Afr Health Sci. 2006 Sep;6(3):177-81. doi: 10.5555/afhs.2006.6.3.177.
Abnormal haemoglobin variants (HbSS,AS,AC,SC,etc) have been known to be common among blacks. Patients with sickle cell disease are often faced with the risk of alloimmunization from allogeneic blood transfusion.
The study was designed to sample students population of African descents for the purpose of updating information on the prevalence of abnormal haemoglobin variants, ABO, and Rh blood groups and compare the results with previously published data.
Standard electrophoretic and haemagglutination techniques were employed in testing the blood samples.
Of the 620 students screened, 80.32% were HbAA and 19.68% HbAS. 22.9% were of blood group A, 17.10% group B, 4.84% group AB and 55.16% group O. 96.77% were Rh.D positive while 3.23% were Rh D negative. Sickle cell gene in homozygous state (HbSS) and other abnormal haemoglobin variants were not encountered in this students population,. Analysis of the students population revealed that 454(73.23%) were females while 166(26.77%) were males. Participants of the age group 26-30 years (35.7%) constituted the majority and in this age group, all blood groups were represented.
There is a gradual decline in the prevalence of abnormal haemoglobin variants in our black population. The frequencies of ABO and Rh blood groups however appeared to be stable and consistent with previous published data.
已知异常血红蛋白变体（HbSS、AS、AC、SC等）在黑人中很常见。镰状细胞病患者经常面临异体输血导致同种免疫的风险。
本研究旨在对非洲裔学生群体进行抽样，以更新有关异常血红蛋白变体、ABO和Rh血型患病率的信息，并将结果与先前发表的数据进行比较。
采用标准电泳和血凝技术检测血样。
在筛查的620名学生中，80.32%为HbAA，19.68%为HbAS。22.9%为A型血，17.10%为B型血，4.84%为AB型血，55.16%为O型血。96.77%为Rh.D阳性，3.23%为Rh D阴性。在该学生群体中未发现纯合状态的镰状细胞基因（HbSS）和其他异常血红蛋白变体。对学生群体的分析显示，454名（73.23%）为女性，166名（26.77%）为男性。26 - 30岁年龄组的参与者（35.7%）占大多数，在这个年龄组中，所有血型都有代表。
我们黑人人群中异常血红蛋白变体的患病率呈逐渐下降趋势。然而，ABO和Rh血型的频率似乎稳定，且与先前发表的数据一致。
