在健康男性受试者中，大脑单胺氧化酶A（MAO A）活性与MAO A基因型不相符的证据。
Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects.
作者信息
Fowler Joanna S, Alia-Klein Nelly, Kriplani Aarti, Logan Jean, Williams Benjamin, Zhu Wei, Craig Ian W, Telang Frank, Goldstein Rita, Volkow Nora D, Vaska Paul, Wang Gene-Jack
机构信息
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
出版信息
Biol Psychiatry. 2007 Aug 15;62(4):355-8. doi: 10.1016/j.biopsych.2006.08.038. Epub 2006 Dec 4.
Abstract
BACKGROUND
A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects.
METHODS
Brain MAO A activity was measured with positron emission tomography and [(11)C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism.
RESULTS
There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes.
CONCLUSIONS
The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
摘要
背景
单胺氧化酶A（MAO A）基因启动子区域的功能性多态性有两个常见等位基因，分别被称为高MAO A基因型和低MAO A基因型。我们报告了首例体内人体研究，以确定健康男性受试者中MAO A基因型与脑MAO A活性之间是否存在关联。
方法
对38名进行了MAO A多态性基因分型的健康成年男性非吸烟者，采用正电子发射断层扫描和[（11）C]氯吉兰测量脑MAO A活性。
结果
高MAO A基因型（n = 26）和低MAO A基因型（n = 12）之间的脑MAO A活性无显著差异。
结论
高MAO A基因型和低MAO A基因型与脑MAO A活性之间缺乏关联，这表明该多态性本身并不会导致健康成年男性受试者脑MAO A活性的差异。
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