Deibel Scott H, McDonald Robert J, Kolla Nathan J
Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
Department of Neuroscience, University of Lethbridge, Lethbridge, AL, Canada.
Front Behav Neurosci. 2020 Mar 17;14:39. doi: 10.3389/fnbeh.2020.00039. eCollection 2020.
This review focuses on the contribution of circadian rhythms to aggression with a multifaceted approach incorporating genetics, neural networks, and behavior. We explore the hypothesis that chronic circadian misalignment is contributing to increased aggression. Genes involved in both circadian rhythms and aggression are discussed as a possible mechanism for increased aggression that might be elicited by circadian misalignment. We then discuss the neural networks underlying aggression and how dysregulation in the interaction of these networks evoked by circadian rhythm misalignment could contribute to aggression. The last section of this review will present recent human correlational data demonstrating the association between chronotype and/or circadian misalignment with aggression. With circadian rhythms and aggression being a burgeoning area of study, we hope that this review initiates more interest in this promising and topical area.
本综述采用综合遗传学、神经网络和行为学的多方面方法，聚焦于昼夜节律对攻击行为的影响。我们探讨了慢性昼夜节律失调导致攻击行为增加的假说。参与昼夜节律和攻击行为的基因被作为昼夜节律失调可能引发攻击行为增加的一种潜在机制进行了讨论。然后，我们讨论了攻击行为背后的神经网络，以及昼夜节律失调引起的这些网络相互作用的失调如何导致攻击行为。本综述的最后一部分将展示近期人类相关性数据，证明昼夜类型和/或昼夜节律失调与攻击行为之间的关联。鉴于昼夜节律与攻击行为是一个新兴的研究领域，我们希望本综述能引发人们对这个有前景且热门领域的更多关注。
