Rader Daniel J
Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.
J Clin Invest. 2006 Dec;116(12):3090-100. doi: 10.1172/JCI30163.
HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.
高密度脂蛋白(HDL)代谢是旨在降低动脉粥样硬化性心血管疾病风险的治疗方法开发的主要靶点。HDL代谢复杂,涉及HDL载脂蛋白的解离和HDL胆固醇代谢。我们对HDL代谢、巨噬细胞胆固醇流出和HDL功能的分子调控的理解取得进展,将带来多种新型治疗方法。