Wang Xinge, Xie Zheng, Zhang Jing, Chen Ying, Li Qi, Yang Qing, Chen Xu, Liu Bing, Xu Shijun, Dong Yu
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
iScience. 2025 Mar 7;28(4):112168. doi: 10.1016/j.isci.2025.112168. eCollection 2025 Apr 18.
Atherosclerosis (AS) is a chronic inflammatory condition associated with lipid deposition. The interaction between abnormal lipid metabolism and the inflammatory response has been identified as the underlying cause of AS. Lipid metabolism disorders are considered the basis of atherosclerotic lesion formation and macrophages are involved in the entire process of AS formation. Macrophages have a high degree of plasticity, and the change of their polarization direction can determine the progress or regression of AS. The disturbances in bioactive lipid metabolism affect the polarization of different phenotypes of macrophages, thus, affecting lipid metabolism and the expression of key signal factors. Therefore, understanding the interaction between lipid metabolism and macrophages as well as their key targets is important for preventing and treating AS and developing new drugs. Recent studies have shown that traditional Chinese medicines play a positive role in the prevention and treatment of AS, providing a basis for clinical individualized treatment.
动脉粥样硬化（AS）是一种与脂质沉积相关的慢性炎症性疾病。异常脂质代谢与炎症反应之间的相互作用已被确定为AS的根本原因。脂质代谢紊乱被认为是动脉粥样硬化病变形成的基础，巨噬细胞参与了AS形成的全过程。巨噬细胞具有高度的可塑性，其极化方向的改变可以决定AS的进展或消退。生物活性脂质代谢的紊乱影响巨噬细胞不同表型的极化，从而影响脂质代谢和关键信号因子的表达。因此，了解脂质代谢与巨噬细胞之间的相互作用及其关键靶点对于预防和治疗AS以及开发新药具有重要意义。最近的研究表明，中药在AS的预防和治疗中发挥着积极作用，为临床个体化治疗提供了依据。
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