[血管通透性因子在人声带息肉中的表达]

[Expression of vascular permeability factor in human vocal cord polyps].

作者信息

Wu Ping, Liu Tao, Zheng Mingxiu, Chen Jing

机构信息

Department of Otolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming,650101, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Sep;20(18):839-41.

PMID:17144494

Abstract

OBJECTIVE

This study aimed to analyse the expression of vascular permeability factor (VPF) in human vocal fold polyps. Meanwhile, we studied the pathogenesis of vocal cord polyp further.

METHOD

The expression of VPF were detected with immunohistochemical staining in the 37 cases with vocal cord polyps and 11 healthy vocal folds tissues (SP method). Meanwhile,the positive results were contrasted.

RESULT

The percent of positive expression of VPF was 51.35 in vocal cord polyps. This expression tended not to be increased greatly compared with the percent of positive expression of VPF (18.18%) in healthy vocal fold (P > 0.05). But,the percent of positive vascular counts of VPF in the vocal cord polyps (56.66 +/- 25.48) %was higher than that in the healthy vocal fold tissues (37.11 +/- 29.52)% (P < 0.05). In the vocal cord polyps , there was no significant difference in the expression of VPF between the male and female( P > 0.05).

CONCLUSION

The VPF may play a key role in the formation of heavy edema of vocal cord polyps. The VPF may be involved in the formation and development of vocal cord polyps . If we can control the produce of VPF in the vocal cord polyps, we may find a new way to treat it.

摘要

目的

本研究旨在分析血管通透性因子（VPF）在人声带息肉中的表达情况。同时，进一步探讨声带息肉的发病机制。

方法

采用免疫组织化学染色（SP法）检测37例声带息肉组织及11例正常声带组织中VPF的表达，并对阳性结果进行对比分析。

结果

声带息肉中VPF阳性表达率为51.35%，与正常声带组织中VPF阳性表达率（18.18%）相比，差异无统计学意义（P>0.05）。但声带息肉中VPF阳性血管计数百分比（56.66±25.48）%高于正常声带组织（37.11±29.52）%，差异有统计学意义（P<0.05）。在声带息肉中，VPF表达在男性和女性之间无显著差异（P>0.05）。