B 细胞慢性淋巴细胞白血病中自身免疫现象与疾病分期及治疗的关系。

Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia.

作者信息

Barcellini Wilma, Capalbo Silvana, Agostinelli Rosa Maria, Mauro Francesca Romana, Ambrosetti Achille, Calori Rossella, Cortelezzi Agostino, Laurenti Luca, Pogliani Enrico Maria, Pedotti Paola, Liso Vincenzo, Girelli Gabriella, Mandelli Franco, Zanella Alberto

机构信息

Department of Haematology, Padiglione Granelli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via F. Sforza 35 20122 Milan, Italy.

出版信息

Haematologica. 2006 Dec;91(12):1689-92.

PMID:17145607

Abstract

The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.

摘要

这项多中心GIMEMA研究的目的是将B细胞慢性淋巴细胞白血病（B-CLL）中的自身免疫并发症（AIC）与疾病分期和治疗相关联。自身免疫性溶血性贫血（129/194例）和自身免疫性血小板减少症（35/194例）通常出现在晚期和接受过多种治疗的疾病中。多变量分析确定年龄超过中位数、C期以及一线和二线治疗为独立危险因素。相比之下，非血液学AIC（30/194例）和自身免疫血清学标志物的存在大多在早期B-CLL中观察到，这表明B-CLL中血液学和非血液学自身免疫现象存在不同的致病机制。