自身免疫性溶血性贫血和免疫性血小板减少性紫癜中慢性淋巴细胞白血病（CLL）表型淋巴细胞的高发生率。
A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura.
作者信息
Mittal Sajjan, Blaylock Morgan G, Culligan Dominic J, Barker Robert N, Vickers Mark A
出版信息
Haematologica. 2008 Jan;93(1):151-2. doi: 10.3324/haematol.11822.
Minor CLL-like clones are found in approximately 3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans' Syndrome, compared with 26 age-matched healthy controls. A population of 'CLL phenotype' was seen in 6/31 patients compared to 1/26 healthy controls (chi(2)=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.
在大约3%的健康个体中可发现微小的慢性淋巴细胞白血病（CLL）样克隆。自身免疫性溶血性贫血（AIHA）和免疫性血小板减少症（ITP）在CLL中很常见，且可能存在因果联系。我们调查了11例原发性AIHA、18例ITP和2例伊文氏综合征患者中CLL表型淋巴细胞的存在情况，并与26名年龄匹配的健康对照进行比较。与1/26名健康对照相比，31名患者中有6名出现了“CLL表型”群体（χ²=3.9；p=0.05）。这类克隆可能在自身免疫性血液疾病的发病机制中起重要作用。
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