Słopień R, Lewandowski K, Kolacz E, Zawilska K, Warenik-Szymankiewicz A
Department of Gynecological Endocrinology, University of Medical Sciences of Poznań, Poznań, Poland.
Gynecol Endocrinol. 2006 Nov;22(11):651-4. doi: 10.1080/09513590601005805.
The present study aimed to assess the fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome (PCOS) and to compare them in obese PCOS patients and women with simple obesity. We studied 19 obese women with PCOS (age: 25.1 +/- 4.6 years, body mass index (BMI): 34.7 +/- 3.9 kg/m2; mean +/- standard deviation) and 20 age- and BMI-matched ovulatory controls. We measured blood levels of 17beta-estradiol, testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose and insulin. The following fibrinolytic tests were also performed: euglobulin clot lysis time, plasminogen level, alpha2-antiplasmin activity, plasminogen activator inhibitor-1 activity, fibrinogen concentration and estimated fibrinolytic activity. Testosterone and LH levels were significantly higher in obese women with PCOS (p < 0.01 and p < 0.001, respectively). The groups did not differ with regard to 17beta-estradiol, prolactin, FSH, DHEAS, TC, TG, HDL-C, LDL-C, glucose and insulin. All of the fibrinolysis parameters with the exception of plasminogen were comparable between the two groups. Serum plasminogen level was lower in obese PCOS patients than in women with simple obesity (p < 0.05). Euglobulin clot lysis time was positively correlated with insulin (r = 0.88, p < 0.05) in both groups. Our results show that fibrinolysis is not suppressed in women with PCOS and that there is no difference in fibrinolytic activity between obese patients with PCOS and women with simple obesity.
本研究旨在评估多囊卵巢综合征（PCOS）肥胖患者的纤溶和代谢系统参数，并将肥胖PCOS患者与单纯肥胖女性进行比较。我们研究了19例肥胖PCOS女性（年龄：25.1±4.6岁，体重指数（BMI）：34.7±3.9kg/m²；均值±标准差）和20例年龄及BMI匹配的排卵对照者。我们检测了血液中17β-雌二醇、睾酮、催乳素、黄体生成素（LH）、卵泡刺激素（FSH）、硫酸脱氢表雄酮（DHEAS）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、葡萄糖和胰岛素的水平。还进行了以下纤溶试验：优球蛋白凝块溶解时间、纤溶酶原水平、α2-抗纤溶酶活性、纤溶酶原激活物抑制剂-1活性、纤维蛋白原浓度和估计纤溶活性。肥胖PCOS女性的睾酮和LH水平显著更高（分别为p<0.01和p<0.001）。两组在17β-雌二醇、催乳素、FSH、DHEAS、TC、TG、HDL-C、LDL-C、葡萄糖和胰岛素方面无差异。除纤溶酶原外，两组所有纤溶参数均具有可比性。肥胖PCOS患者的血清纤溶酶原水平低于单纯肥胖女性（p<0.05）。两组中优球蛋白凝块溶解时间均与胰岛素呈正相关（r=0.88，p<0.05）。我们的结果表明，PCOS女性的纤溶功能未受抑制，肥胖PCOS患者与单纯肥胖女性的纤溶活性无差异。
