Study on the interaction of aromatic dyes with nucleic acids by means of UV, CD and NMR spectroscopies.
作者信息
Yashima E, Tajima T, Suehiro N, Akashi M, Miyauchi N
机构信息
Department of Applied Chemistry, Faculty of Engineering, Kagoshima University, Japan.
出版信息
Nucleic Acids Symp Ser. 1990(22):101-2.
PMID:1714567
Abstract
The interaction of several aromatic cationic dyes such as, ethidium bromide (EB), methylene blue (MB), acridine orange (AO), and Hoechst 33258 with calf-thymus DNA and poly(A)-poly(U) duplex was investigated. The different induced extrinsic Cotton effects (greater than 300 nm) were observed for DNA- and RNA-dye complexes. The binding properties of these complexes were examined by UV, CD, and NMR spectroscopies.
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