接种商业灭活多价疫苗的非家养猫科动物中针对猫细小病毒的中和抗体

Neutralizing antibodies against feline parvoviruses in nondomestic felids inoculated with commercial inactivated polyvalent vaccines.

作者信息

Sassa Yukiko, Fukui Daisuke, Takeshi Kouichi, Miyazawa Takayuki

机构信息

Laboratory of Veterinary Infectious Diseases, Department of Applied Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.

出版信息

J Vet Med Sci. 2006 Nov;68(11):1195-8. doi: 10.1292/jvms.68.1195.

DOI:10.1292/jvms.68.1195

PMID:17146178

Abstract

The virus neutralization (VN) antibody titers of serum samples from 18 individuals representing 8 carnivore species vaccinated with commercial polyvalent vaccines optimized for domestic cats containing inactivated feline panleukopenia virus (FPLV) were evaluated against canine parvovirus type 2 (CPV2). In addition, the titers among 5 individuals from 4 carnivore were evaluated against antigenic variants of feline parvoviruses; FPLV, CPV2, CPV2a, CPV2b, CPV2c, mink enteritis virus type 1 (MEV1) and MEV2. The polyvalent vaccines induced cross-reactive VN titers against antigenic variants of feline parvoviruses in nondomestic felids. However, we observed very low cross-reactive VN antibody in lions and Siberian tigers, therefore we should pay attention to CPV infections in these animals even if they were vaccinated with inactivated FPLV vaccines.

摘要

对18只代表8种食肉动物物种的血清样本进行了病毒中和（VN）抗体效价评估，这些动物接种了针对家猫优化的含有灭活猫泛白细胞减少症病毒（FPLV）的商业多价疫苗，评估其对2型犬细小病毒（CPV2）的中和抗体效价。此外，还评估了来自4种食肉动物的5只个体对猫细小病毒抗原变体的效价；FPLV、CPV2、CPV2a、CPV2b、CPV2c、1型水貂肠炎病毒（MEV1）和MEV2。多价疫苗在非家猫科动物中诱导了针对猫细小病毒抗原变体的交叉反应性VN效价。然而，我们在狮子和东北虎中观察到非常低的交叉反应性VN抗体，因此即使这些动物接种了灭活FPLV疫苗，我们也应注意它们感染CPV的情况。