Baron Georgeann C, Irving Gordon A
The University of Texas Health Science Center, Houston Medical School, Texas, USA.
Pain Pract. 2002 Jun;2(2):129-33. doi: 10.1046/j.1533-2500.2002.02014.x.
The neuroselective effects of tourniquet ischemia/compression in healthy volunteers were evaluated using the automated electrodiagnostic sensory Nerve Conduction Threshold (sNCT) test. The sNCT evaluation generates reliable, painless Current Perception Threshold (CPT) measures. Standardized CPT measures using constant alternating current sinusoid waveform stimulus at 3 different frequencies 5 Hz, 250 Hz, and 2 kHz (NeurometerEG CPT/C Neurotron, Inc. Baltimore, MD) were obtained from 10 individuals at baseline and after 5, 10, 15, and 20 minutes of tourniquet ischemia and 30 minutes post-tourniquet release. The data were analyzed to determine the significance of any changes in CPTs. Increases in CPTs after 15 and 20 minutes of tourniquet ischemia at 2000 Hz and 250 Hz reached statistical significance. There were no significant changes in 5 Hz CPT measures. The results of this study demonstrate the ability of the sNCT test to quantify previously described differential neuroselective effects of tourniquet ischemia on sensory nerve function. Demonstration of statistically significant increases in CPT values at 2000 Hz and 250 Hz secondary to tourniquet ischemia, with no change in 5 Hz CPT values, is consistent with the understanding that 2000 Hz sine wave stimuli activate the large myelinated sensory fibers, 250 Hz sine wave stimuli activate small myelinated sensory fibers, and 5 Hz sine wave stimuli activate small unmyelinated sensory fibers.
使用自动电诊断感觉神经传导阈值（sNCT）测试评估了健康志愿者中止血带缺血/压迫的神经选择性效应。sNCT评估可生成可靠、无痛的电流感知阈值（CPT）测量值。使用3种不同频率（5Hz、250Hz和2kHz）的恒定交流电正弦波刺激（Neurometer EG CPT/C Neurotron公司，马里兰州巴尔的摩）获得标准化CPT测量值，测量对象为10名个体，在基线时以及止血带缺血5、10、15和20分钟后以及止血带松开后30分钟进行测量。对数据进行分析以确定CPT的任何变化的显著性。在2000Hz和250Hz频率下，止血带缺血15和20分钟后CPT升高达到统计学显著性。5Hz CPT测量值无显著变化。本研究结果证明了sNCT测试能够量化先前描述的止血带缺血对感觉神经功能的不同神经选择性效应。止血带缺血继发2000Hz和250Hz频率下CPT值有统计学显著性升高，而5Hz CPT值无变化，这与以下认识一致：2000Hz正弦波刺激激活大的有髓感觉纤维，250Hz正弦波刺激激活小的有髓感觉纤维，5Hz正弦波刺激激活小的无髓感觉纤维。
