Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara, Japan.
Pain Med. 2010 Mar;11(3):472-5. doi: 10.1111/j.1526-4637.2009.00790.x. Epub 2010 Jan 22.
A lidocaine patch is often used for topical anesthesia prior to venipuncture, but needs to be applied for several hours before the puncture, and the site is fixed. A metered-dose lidocaine pump spray could be used to produce cutaneous topical anesthesia. In this study, we compared the anesthesia between the spray and the patch.
Thirteen healthy male volunteers received three treatments of metered-dose 8% lidocaine spray, a lidocaine patch, and no application as control measurement, in a random order separated by at least 2 days. Each treatment was applied topically on the forearm. Sensory nerve fibers (Abeta, Adelta, and C fibers) were evaluated with a series of 5, 250, and 2,000 Hz stimuli using current perception threshold (CPT) before and 30 minutes after each application.
Under the control condition, CPTs measured at baseline and at 30 minutes were similar for 2,000 and 250 Hz stimuli, but significantly reduced for 5 Hz stimulation at 30 minutes. Under patch application, CPTs for 2,000 and 250 Hz stimuli at 30 minutes after application were significantly higher than baseline, while CPTs for 5 Hz stimulation at baseline and 30 minutes after application were similar. Under spray application, CPTs for all stimuli at 30 minutes were significantly higher than baseline.
Similar to the lidocaine patch, the lidocaine spray produces cutaneous weak anesthesia at 30 minutes after treatment. The spray seems to produce local anesthesia faster than the patch.
利多卡因贴剂常用于静脉穿刺前的局部麻醉，但需要在穿刺前数小时应用，并固定在穿刺部位。定量喷雾利多卡因泵可用于产生皮肤局部麻醉。本研究比较了喷雾和贴剂的麻醉效果。
13 名健康男性志愿者以随机顺序在至少 2 天的间隔内接受三种治疗，即定量 8%利多卡因喷雾、利多卡因贴剂和无应用（作为对照测量），分别应用于前臂。使用电流感知阈值（CPT）在应用前和应用后 30 分钟评估感觉神经纤维（Abeta、Adelta 和 C 纤维），使用 5、250 和 2000 Hz 的一系列刺激。
在对照条件下，2000 和 250 Hz 刺激的 CPT 在基线和 30 分钟时相似，但 5 Hz 刺激在 30 分钟时显著降低。在贴剂应用下，应用后 30 分钟时 2000 和 250 Hz 刺激的 CPT 明显高于基线，而 5 Hz 刺激的 CPT 在基线和应用后 30 分钟时相似。在喷雾应用下，所有刺激的 CPT 在 30 分钟时均明显高于基线。
与利多卡因贴剂类似，利多卡因喷雾在治疗后 30 分钟产生皮肤弱麻醉。喷雾似乎比贴剂更快地产生局部麻醉。
