Billiards Saraid S, Pierson Christopher R, Haynes Robin L, Folkerth Rebecca D, Kinney Hannah C
Department of Pathology, Enders Building, Room 1109, Children's Hospital Boston, Boston, MA 02115, USA.
Clin Perinatol. 2006 Dec;33(4):915-33; abstract x-xi. doi: 10.1016/j.clp.2006.10.003.
This article addresses the issue of whether the late preterm infant is more susceptible to gray matter injury induced by hypoxia-ischemia than the term infant. Although different gray matter regions display varying patterns of neuronal injury in the face of hypoxia-ischemia during advancing gestational development, little is known about the specific patterns of injury faced by the late preterm infant. This changing pattern of neuronal vulnerability with age likely reflects developmental changes of susceptibility and protective factors essential for responding to energy deprivation at the molecular, cellular, biochemical, and vascular levels. Future research involving closer examination of the late preterm period is essential to provide a greater understanding of the neuronal vulnerability in the face of hypoxic-ischemic injury.
本文探讨了晚期早产儿是否比足月儿更容易受到缺氧缺血性脑损伤的问题。尽管在妊娠发育过程中，面对缺氧缺血时不同的灰质区域显示出不同的神经元损伤模式，但对于晚期早产儿所面临的具体损伤模式知之甚少。这种神经元易损性随年龄的变化模式可能反映了在分子、细胞、生化和血管水平上对能量剥夺做出反应所必需的易感性和保护因素的发育变化。未来有必要进行更深入研究晚期早产阶段，以更好地了解缺氧缺血性损伤时的神经元易损性。
