Beckley D J, Bloem B R, van Dijk J G, Roos R A, Remler M P
Department of Neurology, School of Medicine, University of California, Davis.
Electroencephalogr Clin Neurophysiol. 1991 Aug;81(4):263-8. doi: 10.1016/0168-5597(91)90012-m.
Postural reflexes in response to sudden toe-up tilts of a supporting forceplate platform were studied in free-standing patients with stage III (N = 5) and stage IV (N = 5) Parkinson's disease and compared to 5 age- and sex-matched normals. Latencies of the short (SL), medium (ML) and long latency (LL) responses were normal in the patients. The normalized mean amplitudes of the ML responses were significantly increased only in the stage IV Parkinson patients (P less than 0.0005). The distal-proximal activation sequence of LL responses observed in all 5 controls was reversed in 1 of the stage III and 4 of the stage IV Parkinson patients. Both the enlargement of the ML response (P less than 0.01) and the inverted activation sequence of LL responses (P less than 0.01) were significantly correlated with severity of the disease. The data establish an association between abnormal modulation of postural reflexes in the lower extremity and clinically rated balance impairment in Parkinson's disease.
在站立位的III期（N = 5）和IV期（N = 5）帕金森病患者中，研究了对支撑测力平台突然向上倾斜的姿势反射，并与5名年龄和性别匹配的正常人进行比较。患者的短潜伏期（SL）、中潜伏期（ML）和长潜伏期（LL）反应的潜伏期正常。仅在IV期帕金森病患者中，ML反应的标准化平均幅度显著增加（P < 0.0005）。在所有5名对照中观察到的LL反应的远端到近端激活顺序，在1名III期和4名IV期帕金森病患者中发生了逆转。ML反应的增大（P < 0.01）和LL反应的反向激活顺序（P < 0.01）均与疾病严重程度显著相关。这些数据表明，帕金森病患者下肢姿势反射的异常调节与临床评定的平衡障碍之间存在关联。
