Zebrafish as a novel model system to study the function of caveolae and caveolin-1 in organismal biology.
作者信息
Frank Philippe G, Lisanti Michael P
机构信息
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 S. 10th Street, BLSB 933, Philadelphia, PA 19107, USA.
出版信息
Am J Pathol. 2006 Dec;169(6):1910-2. doi: 10.2353/ajpath.2006.060923.
Abstract
摘要
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Zebrafish as a novel model system to study the function of caveolae and caveolin-1 in organismal biology.斑马鱼作为一种新型模型系统，用于研究小窝和小窝蛋白-1在生物生物学中的功能。
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Identification of a novel domain at the N terminus of caveolin-1 that controls rear polarization of the protein and caveolae formation.在小窝蛋白-1的N端鉴定出一个新结构域，该结构域可控制该蛋白的后端极化及小窝形成。
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本文引用的文献
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Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate development.小窝蛋白-1α和-1β在脊椎动物早期发育中发挥非冗余作用。
Am J Pathol. 2006 Dec;169(6):2209-22. doi: 10.2353/ajpath.2006.060562.
2
The Caveolin genes: from cell biology to medicine.小窝蛋白基因：从细胞生物学到医学
Ann Med. 2004;36(8):584-95. doi: 10.1080/07853890410018899.
3
Role of caveolae and caveolins in health and disease.小窝和小窝蛋白在健康与疾病中的作用。
Physiol Rev. 2004 Oct;84(4):1341-79. doi: 10.1152/physrev.00046.2003.
4
Cell type-specific occurrence of caveolin-1alpha and -1beta in the lung caused by expression of distinct mRNAs.
J Biol Chem. 2004 Jun 11;279(24):25574-81. doi: 10.1074/jbc.M310807200. Epub 2004 Apr 2.
5
Caveolin regulation of endothelial function.小窝蛋白对内皮功能的调节
Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1179-83. doi: 10.1152/ajplung.00242.2003.
6
Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions.内皮细胞在二维和三维迁移过程中窖蛋白-1的差异性极化
Mol Biol Cell. 2003 Aug;14(8):3156-68. doi: 10.1091/mbc.e02-11-0761. Epub 2003 May 3.
7
Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression.通过小窝蛋白-1表达揭示发育中小鼠卵巢的广泛血管形成。
Dev Dyn. 2002 Sep;225(1):95-9. doi: 10.1002/dvdy.10128.
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Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis.非洲爪蟾（Xenopus laevis）中窖蛋白基因家族的分子克隆与发育表达
Biochemistry. 2002 Jun 25;41(25):7914-24. doi: 10.1021/bi020043n.
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Sites of Ca(2+) wave initiation move with caveolae to the trailing edge of migrating cells.钙离子波起始位点随小窝移动至迁移细胞的后缘。
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Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking.小窝是高度固定的质膜微结构域，不参与组成型内吞运输。
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