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根提取物作为治疗早期白发的潜在候选物。

root extract as a potential candidate for treatment of early graying hair.

作者信息

Thang Nguyen Dinh, Diep Pham Ngoc, Lien Pham Thi Huong, Lien Le Thi

机构信息

Department of Biochemistry and Plant Physiology, Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam; National Key Laboratory of Enzyme and Protein Technology, VNU University of Science, Vietnam National University, Hanoi, Vietnam.

出版信息

J Adv Pharm Technol Res. 2017 Jan-Mar;8(1):8-13. doi: 10.4103/2231-4040.197332.

DOI:10.4103/2231-4040.197332
PMID:28217548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5288971/
Abstract

Despite (PM) has been experiencely used as a drug to treat early graying hair phenomenon in Asian countries for a long time, there is limited study examined the real biological effects of PM on hair graying and . In this study, we investigated the effects of PM root extract (PM-RE) on melanin synthesis in human melanoma SKMEL-28 cells and embryos/larvae of wild-type strain AB zebrafish. We also preliminary revealed the molecular mechanism of early hair graying phenomenon in both and models. Our results showed that PM-RE significantly induced melanin synthesis in melanin-producing SKMEL-28 melanoma cells and also in zebrafish embryos/larvae at 4-day postfertilization through activation of MC1R/MITF/tyrosinase-signaling pathway. We also investigated the differences in genotype between graying hair follicle and black hair follicle of young peoples and found that early hair graying phenomenon may be related to downregulation of MC1R/MITF/tyrosinase pathway. Taken together, we suggested that PM-RE at safe doses could be used as a potential agent for the treatment of early hair graying and other loss pigmentation-related diseases.

摘要

尽管在亚洲国家，何首乌（PM）长期以来一直被用作治疗早期白发现象的药物，但对PM对白发的实际生物学效应进行研究的却很有限。在本研究中，我们调查了何首乌根提取物（PM-RE）对人黑色素瘤SKMEL-28细胞以及野生型AB品系斑马鱼胚胎/幼体黑色素合成的影响。我们还初步揭示了人和斑马鱼模型中早期白发现象的分子机制。我们的结果表明，PM-RE通过激活MC1R/MITF/酪氨酸酶信号通路，显著诱导了产生黑色素的SKMEL-28黑色素瘤细胞以及受精后4天的斑马鱼胚胎/幼体中的黑色素合成。我们还研究了年轻人白发毛囊和黑发毛囊之间的基因型差异，发现早期白发现象可能与MC1R/MITF/酪氨酸酶通路的下调有关。综上所述，我们认为安全剂量的PM-RE可作为治疗早期白发及其他色素脱失相关疾病的潜在药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/81eb05b09a71/JAPTR-8-8-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/d6527db44239/JAPTR-8-8-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/701174849bf0/JAPTR-8-8-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/93bb2d4d2fba/JAPTR-8-8-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/1b80a1d03806/JAPTR-8-8-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/11b85b0986b4/JAPTR-8-8-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/81eb05b09a71/JAPTR-8-8-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/d6527db44239/JAPTR-8-8-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/701174849bf0/JAPTR-8-8-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/93bb2d4d2fba/JAPTR-8-8-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/1b80a1d03806/JAPTR-8-8-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/11b85b0986b4/JAPTR-8-8-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0073/5288971/81eb05b09a71/JAPTR-8-8-g008.jpg

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本文引用的文献

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Biomed Res Int. 2015;2015:651048. doi: 10.1155/2015/651048. Epub 2015 Nov 10.
2
Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum.何首乌促进毛发生长的活性及其机制
Evid Based Complement Alternat Med. 2015;2015:517901. doi: 10.1155/2015/517901. Epub 2015 Jul 30.
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Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway.类Deltex-3（DTX3L）通过FAK/PI3K/AKT而非MEK/ERK途径刺激黑色素瘤转移。
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关于……肝毒性的影响因素
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Promotion effect of constituents from the root of Polygonum multiflorum on hair growth.何首乌提取物对毛发生长的促进作用。
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Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02.何首乌及其炮制品和主要成分对人肝细胞系 L02 脂肪变性的调节作用。
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