Schüz Joachim, Jacobsen Rune, Olsen Jørgen H, Boice John D, McLaughlin Joseph K, Johansen Christoffer
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
J Natl Cancer Inst. 2006 Dec 6;98(23):1707-13. doi: 10.1093/jnci/djj464.
The widespread use of cellular telephones has heightened concerns about possible adverse health effects. The objective of this study was to investigate cancer risk among Danish cellular telephone users who were followed for up to 21 years.
This study is an extended follow-up of a large nationwide cohort of 420,095 persons whose first cellular telephone subscription was between 1982 and 1995 and who were followed through 2002 for cancer incidence. Standardized incidence ratios (SIRs) were calculated by dividing the number of observed cancer cases in the cohort by the number expected in the Danish population.
A total of 14,249 cancers were observed (SIR = 0.95; 95% confidence interval [CI] = 0.93 to 0.97) for men and women combined. Cellular telephone use was not associated with increased risk for brain tumors (SIR = 0.97), acoustic neuromas (SIR = 0.73), salivary gland tumors (SIR = 0.77), eye tumors (SIR = 0.96), or leukemias (SIR = 1.00). Among long-term subscribers of 10 years or more, cellular telephone use was not associated with increased risk for brain tumors (SIR = 0.66, 95% CI = 0.44 to 0.95), and there was no trend with time since first subscription. The risk for smoking-related cancers was decreased among men (SIR = 0.88, 95% CI = 0.86 to 0.91) but increased among women (SIR = 1.11, 95% CI = 1.02 to 1.21). Additional data on income and smoking prevalence, primarily among men, indicated that cellular telephone users who started subscriptions in the mid-1980s appeared to have a higher income and to smoke less than the general population.
We found no evidence for an association between tumor risk and cellular telephone use among either short-term or long-term users. Moreover, the narrow confidence intervals provide evidence that any large association of risk of cancer and cellular telephone use can be excluded.
移动电话的广泛使用引发了人们对其可能产生的健康不良影响的担忧。本研究的目的是调查随访长达21年的丹麦移动电话用户的癌症风险。
本研究是对一个大型全国性队列的长期随访，该队列包括420,095人，他们的首次移动电话订阅时间在1982年至1995年之间，并随访至2002年以观察癌症发病率。标准化发病比（SIR）通过将队列中观察到的癌症病例数除以丹麦人群中预期的病例数来计算。
男性和女性合计共观察到14,249例癌症（SIR = 0.95；95%置信区间[CI] = 0.93至0.97）。使用移动电话与脑肿瘤（SIR = 0.97）、听神经瘤（SIR = 0.73）、唾液腺肿瘤（SIR = 0.77）、眼肿瘤（SIR = 0.96）或白血病（SIR = 1.00）风险增加无关。在订阅10年或更长时间的长期用户中，使用移动电话与脑肿瘤风险增加无关（SIR = 0.66，95% CI = 0.44至0.95），并且自首次订阅以来没有随时间变化的趋势。男性中与吸烟相关癌症的风险降低（SIR = 0.88，95% CI = 0.86至0.91），但女性中风险增加（SIR = 1.11，95% CI = 1.02至1.21）。关于收入和吸烟流行率的更多数据，主要是关于男性的数据，表明在20世纪80年代中期开始订阅移动电话的用户似乎比一般人群收入更高且吸烟更少。
我们没有发现短期或长期用户中肿瘤风险与使用移动电话之间存在关联的证据。此外，狭窄的置信区间提供了证据，表明可以排除癌症风险与使用移动电话之间的任何大的关联。
