International Agency for Research on Cancer (IARC/WHO), Environment and Lifestyle Epidemiology Branch, Lyon, France.
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
J Natl Cancer Inst. 2022 May 9;114(5):704-711. doi: 10.1093/jnci/djac042.
The ongoing debate of whether use of cellular telephones increases the risk of developing a brain tumor was recently fueled by the launch of the fifth generation of wireless technologies. Here, we update follow-up of a large-scale prospective study on the association between cellular telephone use and brain tumors.
During 1996-2001, 1.3 million women born in 1935-1950 were recruited into the study. Questions on cellular telephone use were first asked in median year 2001 and again in median year 2011. All study participants were followed via record linkage to National Health Services databases on deaths and cancer registrations (including nonmalignant brain tumors).
During 14 years follow-up of 776 156 women who completed the 2001 questionnaire, a total of 3268 incident brain tumors were registered. Adjusted relative risks for ever vs never cellular telephone use were 0.97 (95% confidence interval = 0.90 to 1.04) for all brain tumors, 0.89 (95% confidence interval = 0.80 to 0.99) for glioma, and not statistically significantly different to 1.0 for meningioma, pituitary tumors, and acoustic neuroma. Compared with never-users, no statistically significant associations were found, overall or by tumor subtype, for daily cellular telephone use or for having used cellular telephones for at least 10 years. Taking use in 2011 as baseline, there were no statistically significant associations with talking for at least 20 minutes per week or with at least 10 years use. For gliomas occurring in the temporal and parietal lobes, the parts of the brain most likely to be exposed to radiofrequency electromagnetic fields from cellular telephones, relative risks were slightly below 1.0.
Our findings support the accumulating evidence that cellular telephone use under usual conditions does not increase brain tumor incidence.
随着第五代无线技术的推出，关于使用移动电话是否会增加罹患脑瘤风险的持续争论最近再次升温。在这里，我们更新了一项关于使用移动电话与脑瘤之间关联的大规模前瞻性研究的随访结果。
1996 年至 2001 年间，招募了 130 万名出生于 1935 年至 1950 年的女性参加该研究。首次在中位数年份 2001 年询问关于移动电话使用的问题，并在中位数年份 2011 年再次询问。通过与国家卫生服务数据库（包括非恶性脑瘤）的记录链接，对所有研究参与者进行随访，以了解死亡和癌症登记情况。
在对完成 2001 年问卷的 776156 名女性进行了 14 年的随访后，共登记了 3268 例脑瘤病例。与从未使用过移动电话的人相比，经常使用移动电话的人罹患所有脑瘤的调整后的相对风险为 0.97（95%置信区间为 0.90 至 1.04），罹患神经胶质瘤的调整后的相对风险为 0.89（95%置信区间为 0.80 至 0.99），而脑膜瘤、垂体瘤和听神经瘤的风险与 1.0 无统计学差异。总体或按肿瘤亚型分析，每天使用移动电话或使用移动电话至少 10 年与脑瘤风险均无统计学显著关联。以 2011 年的使用情况为基线，每周通话至少 20 分钟或使用时间至少 10 年与脑瘤发生均无统计学显著关联。对于发生在颞叶和顶叶的胶质瘤，这些大脑部位最有可能受到来自移动电话的射频电磁场的暴露，其相对风险略低于 1.0。
我们的研究结果支持越来越多的证据，即通常情况下使用移动电话不会增加脑瘤的发病率。
