Tomonaga T, Nomura F
Department of Molecular Diagnosis (F8), Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, Japan.
Histol Histopathol. 2007 Feb;22(2):191-7. doi: 10.14670/HH-22.191.
Chromosomal instability (CIN) has been recognized as a hallmark of human cancer and is caused by continuous chromosome missegregation during mitosis. Proper chromosome segregation requires a physical connection between spindle microtubules and centromeric DNA and this attachment occurs at proteinaceous structures called kinetochore. Thus, defect in kinetochore function is a candidate source for CIN and the generation of aneuploidy. Recently, a number of kinetochore components have been shown to be mutated and/or aberrantly expressed in human cancers, which suggests an important role of kinetochore for CIN and carcinogenesis. In this article, we will discuss about how kinetochore dysfunction causes CIN and might lead to the development of cancer.
染色体不稳定（CIN）已被公认为人类癌症的一个标志，它是由有丝分裂期间持续的染色体错分离引起的。正确的染色体分离需要纺锤体微管与着丝粒DNA之间建立物理连接，而这种连接发生在称为动粒的蛋白质结构上。因此，动粒功能缺陷是CIN和非整倍体产生的一个潜在原因。最近，一些动粒成分已被证明在人类癌症中发生突变和/或异常表达，这表明动粒在CIN和致癌作用中起着重要作用。在本文中，我们将讨论动粒功能障碍如何导致CIN并可能导致癌症的发生。
