Stepan Holger, Wallukat Gerd, Schultheiss Heinz-Peter, Faber Renaldo, Walther Thomas
Department of Obstetrics and Gynecology, University of Leipzig, Germany.
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
J Reprod Immunol. 2007 Apr;73(2):130-134. doi: 10.1016/j.jri.2006.08.084. Epub 2006 Dec 5.
Initial studies have demonstrated the significance of the agonistic angiotensin II receptor AT1 autoantibody (AT1-AA) in preeclampsia, although it is unclear what factors induce its generation. Since the epitope recognized by AT1-AA shares high homology with parvovirus B19 (PVB19) capsid proteins, we have investigated the relationship between the presence of AT1-AA in maternal circulation and PVB19 sero-prevalence in normal and abnormal pregnancy. We determined the parvovirus IgG sero-prevalence in normal pregnancies in the second trimester and those with abnormal uterine perfusion that are at risk for preeclampsia. Secondly, pregnancies at delivery with preeclampsia or intrauterine growth restriction were included. All women with normal perfusion were AT1-AA-negative and 80% were parvovirus-IgG-positive. Sixty-three percent of pregnancies with abnormal uterine perfusion were AT1-AA-positive and 71% IgG-positive. Fifty-two percent of the IgG-positive pregnancies in this subgroup were also AT1-AA-positive, and 9 of the 10 parvovirus IgG-negative women were AT1-AA-positive. In the third trimester, 87% of pregnancies with manifest disease were AT1-AA-positive and 58% IgG-positive. While 79% of the PVB19 IgG-positive pregnancies were also AT1-AA-positive, all parvovirus IgG-negative women were AT1-AA-positive. In all groups, AT1-AA activity did not differ between parvovirus IgG-negative and positive women. We find parvovirus IgG-positive pregnant women in all subgroups without relation to AT1-AA presence. This favors AT1-AA generation to be independent of epitope mimicry between parvovirus B19 capsid proteins and the AT1 receptor.
初步研究已证明激动性血管紧张素 II 受体 AT1 自身抗体（AT1-AA）在子痫前期中的重要性，尽管尚不清楚是什么因素诱导其产生。由于 AT1-AA 识别的表位与细小病毒 B19（PVB19）衣壳蛋白具有高度同源性，我们研究了母体循环中 AT1-AA 的存在与正常和异常妊娠中 PVB19 血清阳性率之间的关系。我们测定了孕中期正常妊娠以及有子痫前期风险的子宫灌注异常妊娠中的细小病毒 IgG 血清阳性率。其次，纳入了分娩时患有子痫前期或胎儿生长受限的妊娠。所有灌注正常的女性 AT1-AA 均为阴性，80% 细小病毒-IgG 为阳性。子宫灌注异常的妊娠中有 63% AT1-AA 为阳性，71% IgG 为阳性。该亚组中 IgG 阳性妊娠的 52% 也 AT1-AA 为阳性，10 名细小病毒 IgG 阴性女性中有 9 名 AT1-AA 为阳性。在孕晚期，有明显疾病的妊娠中有 87% AT1-AA 为阳性，58% IgG 为阳性。虽然 79% 的 PVB19 IgG 阳性妊娠也 AT1-AA 为阳性，但所有细小病毒 IgG 阴性女性 AT1-AA 均为阳性。在所有组中，细小病毒 IgG 阴性和阳性女性之间的 AT1-AA 活性没有差异。我们发现在所有亚组中细小病毒 IgG 阳性的孕妇与 AT1-AA 的存在无关。这表明 AT1-AA 的产生独立于细小病毒 B19 衣壳蛋白与 AT1 受体之间的表位模拟。
