Weiss Elisabeth, Siebers Jeffrey V, Keall Paul J
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Radiother Oncol. 2007 Jan;82(1):55-62. doi: 10.1016/j.radonc.2006.10.021. Epub 2006 Dec 5.
To analyse the supposed benefits of low over high photon energies for the radiotherapy of lung cancer.
For 13 patients, 6- and 18-MV IMRT planning was performed using identical planning objectives and dose constraints. Plans were compared according to dose-volume histogram (DVH) analysis including conformity and homogeneity indices (CI and HI) and overall plan quality (composite score CS), considering also magnitude and location of planning target volumes (PTVs).
With 6-MV plans, CSs were better in 11/13, HIs in 10/13 and CIs in 6/13 patients compared with 18-MV plans. Six-MV plans resulted in a better normal tissue sparing except for specified dose levels to the thorax and spinal cord. On average differences between 6 and 18 MV both for the PTV and normal tissues were not statistically significant (p>0.05). Considering size and location of the PTVs as well as their relative position to normal tissue, overall no significant differences between 6 and 18 MV were observed.
On average no clinically or statistically significant differences between 6- and 18-MV plans were observed. High photon energies should therefore not be excluded a priori when a dose-calculation algorithm is utilized that accurately accounts for heterogeneities.
