Reed Simon H, Gillette Thomas G
The Department of Pathology, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom.
DNA Repair (Amst). 2007 Feb 4;6(2):149-56. doi: 10.1016/j.dnarep.2006.10.026. Epub 2006 Dec 5.
It is clear that components of the proteasome and the ubiquitin proteasome pathway play a direct mechanistic role in the regulation of a variety of DNA repair processes. Intriguingly, a wealth of evidence suggests that this is also the case during the regulation of gene transcription. Here we review our current understanding of how the ubiquitin proteasome pathway influences nucleotide excision repair, and discuss how studies that investigate the role of this pathway in the regulation of gene transcription might also contribute to our mechanistic understanding of its role in DNA repair.
很明显，蛋白酶体的组成成分和泛素蛋白酶体途径在多种DNA修复过程的调控中发挥着直接的机制作用。有趣的是，大量证据表明在基因转录调控过程中也是如此。在这里，我们回顾了目前对泛素蛋白酶体途径如何影响核苷酸切除修复的理解，并讨论了研究该途径在基因转录调控中作用的研究如何也可能有助于我们从机制上理解其在DNA修复中的作用。
