Wada Takehiko, Hashimoto Yusuke, Sato Hirofumi, Inoue Yoshihisa
PRESTO, JST, Yamada-oka, Suita 565-0871, Japan.
Nucleic Acids Symp Ser (Oxf). 2004(48):27-8. doi: 10.1093/nass/48.1.27.
A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.
一种使用肽核酸（PRNA）的新型核酸模型已被设计并合成，该模型包含5-氨基-5-脱氧核糖核苷作为核酸识别位点，并且由D-谷氨酸（D-PRNA）而非L-谷氨酸（L-PRNA）组成主链结构。基于γ-谷氨酸主链的手性对圆二色光谱（CD光谱）所阐明的结构的影响，阐明了D-PRNA和L-PRNA寡聚物之间的差异。
