Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.
作者信息
Shuto Satoshi, Tamura Yutaka, Yamamoto Yuji, Kodama Tetsuya, Hoshika Shuichi, Ichikawa Satoshi, Ueno Yoshihito, Ohtsuka Eiko, Komatsu Yasuo, Matsuda Akira
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2004(48):67-8. doi: 10.1093/nass/48.1.67.
PMID:17150481
Abstract
A novel sugar-modified thymidine analogue, 3'-deoxy-4'-C-(2-hydroxyethyl)thymidine (X), was designed and synthesized to show that it can stabilize hairpin structures when it is present in the loop moiety, probably due to the flexibility of the one-carbon-elongated 4'-branched structure.
摘要
Zotero 插件