4'',6''-不饱和环状ADP-碳环核糖的合成及生物活性
Synthesis and biological activity of 4'',6''-unsaturated cyclic ADP-carbocyclic-ribose.
作者信息
Kudoh Takashi, Murayama Takashi, Matsuda Akira, Shuto Satoshi
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2005(49):25-6. doi: 10.1093/nass/49.1.25.
PMID:17150615
Abstract
4'',6''-Unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.
摘要
基于先前的构效关系研究，4'',6''-不饱和环状ADP-碳环核糖（3）被设计为细胞内钙动员第二信使环状ADP-核糖的新型结构类似物，并成功合成。
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