通过光开关错配结合配体控制DNA杂交
Control of DNA hybridization by photoswitchable mismatch binding ligands.
作者信息
Dohno Chikara, Uno Shin-nosuke, Nakatani Kazuhiko
机构信息
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2006(50):87-8. doi: 10.1093/nass/nrl043.
PMID:17150830
Abstract
We herein demonstrate that mismatch binding ligands (MBL) can function as a molecular glue which brings two single stranded DNA (ssDNA) together to form the double stranded DNA (dsDNA). Incorporation of a photoisomerizable azobenzene linkage provides further ability of reversibly controlling duplex stability with light.
摘要
我们在此证明，错配结合配体（MBL）可以作为分子胶水，将两条单链DNA（ssDNA）结合在一起形成双链DNA（dsDNA）。引入可光异构化的偶氮苯连接键可进一步实现用光可逆控制双链稳定性的能力。
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