萘啶：咪唑并吡啶嘧啶碱基对的杂交特性与酶促识别

Hybridization properties and enzymatic recognitions of naphthyridine:imidazopyridopyrimidine base pairs.

作者信息

Ogata Shintaro, Kuramoto Kazuyuki, Inoue Naonori, Minakawa Noriaki, Matsuda Akira

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

出版信息

Nucleic Acids Symp Ser (Oxf). 2006(50):153-4. doi: 10.1093/nass/nrl076.

DOI:10.1093/nass/nrl076

PMID:17150863

Abstract

We describe the synthesis of 1,8-naphthyridine C-nucleosides, Na-N(O) and Na-O(N), and full details of hybridization properties of the duplexes containing naphthyridine:imidazopyridopyrimidine pairs. The desired compounds were obtained from Na-O(N) derivative 1 via conversions of the substituents of 2- and 7-positions, respectively. The 17mer duplex containing one Na-O(O):Im-N(N) pair in the center was stabilized by +11.4 degrees C relative to that containing a T:A pair, and this value was highest among the naphthyridine:imidazopyridopyrimidine pairs.

摘要

我们描述了1,8-萘啶C-核苷Na-N(O)和Na-O(N)的合成，以及含萘啶：咪唑并吡啶嘧啶对的双链体杂交特性的详细信息。所需化合物分别通过2-位和7-位取代基的转化从Na-O(N)衍生物1获得。中心含有一对Na-O(O):Im-N(N)的17聚体双链体相对于含有T:A对的双链体稳定了11.4摄氏度，该值在萘啶：咪唑并吡啶嘧啶对中是最高的。