通过Klenow片段对由四个氢键组成的非天然咪唑并吡啶嘧啶：萘啶碱基对的选择性识别。
Selective recognition of unnatural imidazopyridopyrimidine:naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.
作者信息
Minakawa Noriaki, Ogata Shintaro, Takahashi Mayumi, Matsuda Akira
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
J Am Chem Soc. 2009 Feb 11;131(5):1644-5. doi: 10.1021/ja807391g.
In this work, we investigated how thermally stable ImO(N):NaN(O) and ImN(O):NaO(N) pairs are recognized by the Klenow fragment (KF). As a result, these complementary base pairs, especially the ImN(O):NaO(N) pair, were recognized selectively due to the four hydrogen bonds between the nucleobases and the shape complementarity of the Im:Na pair similar to the purine:pyrimidine base pair.
在本研究中，我们探究了热稳定的异咪唑酮（ImO(N)）: 硝酸钠（NaN(O)）和异咪唑腈（ImN(O)）: 亚硝酸钠（NaO(N)）碱基对是如何被klenow片段（KF）识别的。结果表明，由于碱基之间的四个氢键以及类似于嘌呤:嘧啶碱基对的Im:Na碱基对的形状互补性，这些互补碱基对，尤其是ImN(O):NaO(N)碱基对，能够被选择性识别。
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