Hikishima Sadao, Kuramoto Kazuyuki, Minakawa Noriaki, Matsuda Akira
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Nucleic Acids Symp Ser (Oxf). 2004(48):295-6. doi: 10.1093/nass/48.1.295.
As our continuing study to develop base pairing motifs which stabilize and regulate DNA structure, we designed novel 1,8-naphthyridine C-nucleosides possessing Na-O(N) and Na-N(O) bases. These C-nucleosides formed two sets of naphthyridine:imidazopyridopyrimidine base pairing motifs (Na-O(N):Im-N(O) and Na-N(O):Im-O(N)) with four hydrogen bonds, and duplexes containing the pairs were markedly thermally stabilized independent of the manner in which the new pairs are incorporated.
作为我们开发稳定和调节DNA结构的碱基配对基序的持续研究，我们设计了具有Na-O(N)和Na-N(O)碱基的新型1,8-萘啶C-核苷。这些C-核苷形成了两组具有四个氢键的萘啶：咪唑并吡啶嘧啶碱基配对基序（Na-O(N):Im-N(O)和Na-N(O):Im-O(N)），并且包含这些碱基对的双链体无论新碱基对的掺入方式如何都具有显著的热稳定性。
