Buck K J, Harris R A
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
Alcohol Clin Exp Res. 1991 Jun;15(3):460-70. doi: 10.1111/j.1530-0277.1991.tb00544.x.
Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA-activated chloride channels, voltage-sensitive calcium channels, NMDA-activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.
本文综述了神经元组织对慢性乙醇暴露的细胞反应。关于乙醇急性作用的适应性反应的证据在五个系统中是可得的：GABA激活的氯离子通道、电压敏感性钙通道、NMDA激活的阳离子通道、通过刺激性鸟嘌呤核苷酸结合蛋白偶联的受体以及膜脂质有序性。我们认为，这些适应性反应中至少有一些是由于乙醇在基因表达水平上的作用而发生的。
