阿拉斯加原住民肝细胞癌患者中的乙型肝炎病毒基因型：F基因型占优势
Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F.
作者信息
Livingston Stephen E, Simonetti Josephine P, McMahon Brian J, Bulkow Lisa R, Hurlburt Kathy J, Homan Chriss E, Snowball Mary M, Cagle Henry H, Williams James L, Chulanov Vladimir P
机构信息
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA.
出版信息
J Infect Dis. 2007 Jan 1;195(1):5-11. doi: 10.1086/509894. Epub 2006 Nov 21.
BACKGROUND
The development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection has been associated with specific HBV genotypes and the presence of specific mutations.
METHODS
From a cohort of Alaska Native people with chronic HBV infection, we genotyped 47 patients with HCC and 1129 patients without HCC, and we tested patients with HCC and control patients for mutations in the basal core promoter and precore regions.
RESULTS
Genotype F was found in 68% of patients with HCC, versus 18% of those without HCC (P<.001). For patients with genotype F, the median age at diagnosis of HCC was lower than that for patients with other genotypes (22.5 vs. 60 years, respectively; P=.002). Overall, there were no significant differences in the number of basal core promoter and precore region mutations between patients with HCC and control patients.
CONCLUSIONS
We found a significant association between genotype F and the development of HCC among Alaska Native people with chronic HBV infection but no significant association between HCC and basal core promoter or precore mutations in genotype F.
背景
慢性乙型肝炎病毒（HBV）感染患者肝细胞癌（HCC）的发生与特定的HBV基因型及特定突变的存在有关。
方法
在一组慢性HBV感染的阿拉斯加原住民队列中，我们对47例HCC患者和1129例非HCC患者进行了基因分型，并检测了HCC患者和对照患者的核心启动子和前核心区的突变情况。
结果
68%的HCC患者为F基因型，而无HCC患者中这一比例为18%（P<0.001）。对于F基因型患者，HCC诊断时的中位年龄低于其他基因型患者（分别为22.5岁和60岁；P = 0.002）。总体而言，HCC患者与对照患者之间核心启动子和前核心区突变数量无显著差异。
结论
我们发现F基因型与慢性HBV感染的阿拉斯加原住民中HCC的发生存在显著关联，但HCC与F基因型的核心启动子或前核心突变之间无显著关联。
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