Abisi S, Tan J, Burnand K G
Academic Department of Surgery, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
Br J Surg. 2007 Feb;94(2):194-7. doi: 10.1002/bjs.5619.
The aim of this study was to determine the success of excision and meshed skin grafting for chronic leg ulcers. The effects of different ulcer aetiology and ulcer size on outcome were also assessed.
All patients who had excision and mesh grafting for chronic leg ulceration between January 1996 and December 2004 at St Thomas' Hospital were reviewed. Recurrence was classified as any breakdown of the ulcer during follow-up.
Sixty-two patients with 100 chronic leg ulcers underwent operation. Seventy-two of the ulcers were venous and the median ulcer size was 36 (range 1.5-192) cm2. Only three patients left the hospital with their ulcers unhealed, but ulcers had recurred in 28 (28 per cent) by 2 months. A further 17 ulcers recurred later, with just over half (55 per cent) remaining healed by 5 years. There was no difference between the recurrence rates of venous ulcers and ulcers of other aetiologies (P=0.980), or large (more than 10 cm2) and small ulcers (P=0.686).
Wide local excision and meshed skin grafting benefitted over half of these patients with refractory leg ulcers. Recurrence was most likely to occur in the first 2 months and, provided that ulcers were healed at this time, there was a low rate of further breakdown.
本研究旨在确定切除及网状植皮治疗慢性腿部溃疡的成功率。同时评估不同溃疡病因及溃疡大小对治疗结果的影响。
回顾了1996年1月至2004年12月在圣托马斯医院接受慢性腿部溃疡切除及网状植皮手术的所有患者。复发被定义为随访期间溃疡的任何破溃。
62例患者的100处慢性腿部溃疡接受了手术。其中72处溃疡为静脉性溃疡,溃疡面积中位数为36(范围1.5 - 192)平方厘米。仅有3例患者出院时溃疡未愈合,但到2个月时28例(28%)溃疡复发。另有17例溃疡随后复发,到5年时略超过一半(55%)的溃疡仍愈合良好。静脉性溃疡与其他病因所致溃疡的复发率之间无差异(P = 0.980),大溃疡(面积超过10平方厘米)与小溃疡的复发率之间也无差异(P = 0.686)。
广泛局部切除及网状植皮使超过一半的难治性腿部溃疡患者受益。复发最有可能发生在最初2个月内,并且如果此时溃疡已愈合,进一步破溃的发生率较低。