Wood M K, Davies D M
Plastic and Reconstructive Surgery Unit, Charing Cross Hospital, London.
Ann R Coll Surg Engl. 1995 May;77(3):222-3.
Chronic leg ulcers are a common problem for which many different forms of treatment have been used. In this study we reviewed the results of split-skin grafting of ulcers of different aetiologies; 26 patients were reviewed. The mean duration of ulceration was 27.5 months. Of the 28 ulcers, ten were due to venous disease, three arterial disease, six rheumatoid arthritis, seven traumatic, and two diabetic. Healing rates of 85% for traumatic and 67% for rheumatoid ulcers were achieved, whereas rates of only 20% and 33% were achieved for venous and arterial ulcers (P < 0.02 Fisher's exact test). We conclude that in the presence of vascular disease, split-skin grafting is not an effective treatment for chronic leg ulceration. Vascular assessment and treatment should be carried out before attempting skin grafting.
慢性腿部溃疡是一个常见问题，针对此问题已经采用了许多不同的治疗方法。在本研究中，我们回顾了不同病因溃疡的中厚皮片移植结果；共对26例患者进行了回顾。溃疡的平均持续时间为27.5个月。在28处溃疡中，10处由静脉疾病引起，3处由动脉疾病引起，6处由类风湿性关节炎引起，7处由创伤引起，2处由糖尿病引起。创伤性溃疡的愈合率为85%，类风湿性溃疡的愈合率为67%，而静脉性和动脉性溃疡的愈合率仅为20%和33%（Fisher精确检验，P<0.02）。我们得出结论，在存在血管疾病的情况下，中厚皮片移植不是慢性腿部溃疡的有效治疗方法。在尝试皮肤移植之前，应进行血管评估和治疗。
