Reĭkhardt B A, Kulikova O G, Beliavtseva L M, Borodkin Iu S
Biull Eksp Biol Med. 1991 May;111(5):483-5.
It has been shown that ethylnorantifein and its structural analogues with opposite effects on long term memory reduce the activity of membrane bound phosphodiesterase cAMP with high and low affinity and exert the same directed influence on lipids peroxidation in membranes. A positive correlation was observed only between the action of these substances on the long term memory and their influence on the RNA synthesis in the rat brain nuclei. Ethylnorantifein and its demethylated analogues increased RNA synthesizing activity while allyl- and propylnorantifeins decreased it. The molecular mechanisms of memory effects of neuroactive substances are discussed.
已表明，乙基去甲安非他明及其对长期记忆有相反作用的结构类似物，以高亲和力和低亲和力降低膜结合磷酸二酯酶cAMP的活性，并对膜中的脂质过氧化产生相同的定向影响。仅在这些物质对长期记忆的作用与其对大鼠脑细胞核中RNA合成的影响之间观察到正相关。乙基去甲安非他明及其去甲基类似物增加了RNA合成活性，而烯丙基和丙基去甲安非他明则降低了该活性。讨论了神经活性物质记忆效应的分子机制。
