Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA.
作者信息
Xue Liang, Greenberg Marc M
机构信息
Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
出版信息
Angew Chem Int Ed Engl. 2007;46(4):561-4. doi: 10.1002/anie.200603454.
Abstract
摘要
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Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA.使用荧光传感器确定2-脱氧核糖内酯是氧化损伤DNA中产生的主要碱不稳定脱氧核糖损伤。
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Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial.检测源自呋喃活性代谢物顺式-2-丁烯-1,4-二醛的DNA加合物。
Chem Res Toxicol. 2006 Mar;19(3):414-20. doi: 10.1021/tx050302k.
2
2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release.X射线辐照DNA中的2-脱氧核糖内酯损伤：通过催化释放5-亚甲基-2-呋喃酮进行定量测定。
Angew Chem Int Ed Engl. 2005 Sep 26;44(38):6210-3. doi: 10.1002/anie.200501956.
3
Selective detection of 2-deoxyribonolactone in DNA.DNA中2-脱氧核糖内酯的选择性检测。
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Analysis of M1G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry.通过醛反应性探针标记和液相色谱串联质谱法分析DNA中的M1G-dR
Chem Res Toxicol. 2005 Jan;18(1):51-60. doi: 10.1021/tx049853l.
5
The release of 5-methylene-2-furanone from irradiated DNA catalyzed by cationic polyamines and divalent metal cations.由阳离子多胺和二价金属阳离子催化的辐照DNA释放5-亚甲基-2-呋喃酮。
Radiat Res. 2005 Jan;163(1):85-9. doi: 10.1667/rr3288.
6
Effects of the C4'-oxidized abasic site on replication in Escherichia coli. An unusually large deletion is induced by a small lesion.C4'-氧化无碱基位点对大肠杆菌复制的影响。一个小损伤诱导出异常大的缺失。
Biochemistry. 2004 Nov 2;43(43):13621-7. doi: 10.1021/bi048337r.
7
Evidence for glycosidic bond rotation in a nucleobase peroxyl radical and its effect on tandem lesion formation.核碱基过氧自由基中糖苷键旋转的证据及其对串联损伤形成的影响。
J Org Chem. 2004 Oct 15;69(21):6974-8. doi: 10.1021/jo0492158.
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Mutagenic effects of 2-deoxyribonolactone in Escherichia coli. An abasic lesion that disobeys the A-rule.2-脱氧核糖内酯对大肠杆菌的诱变作用。一种违反A规则的无碱基损伤。
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Tandem lesions are the major products resulting from a pyrimidine nucleobase radical.串联损伤是嘧啶核苷酸碱基自由基产生的主要产物。
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Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes.2-脱氧核糖内酯与其β-消除产物通过碱基切除修复酶的交联作用。
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