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Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA.

作者信息

Xue Liang, Greenberg Marc M

机构信息

Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.

出版信息

Angew Chem Int Ed Engl. 2007;46(4):561-4. doi: 10.1002/anie.200603454.

DOI:10.1002/anie.200603454
PMID:17154191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1780038/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/8304f839b04f/nihms-15931-0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/2582fd6cb2f2/nihms-15931-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/be62cef61c63/nihms-15931-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/8a7720226d01/nihms-15931-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/733c4b274b9a/nihms-15931-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/379ed701b937/nihms-15931-0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/451730690b78/nihms-15931-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/2c8493095214/nihms-15931-0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/b42d0c3ccc79/nihms-15931-0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/8304f839b04f/nihms-15931-0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/2582fd6cb2f2/nihms-15931-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/be62cef61c63/nihms-15931-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/8a7720226d01/nihms-15931-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/733c4b274b9a/nihms-15931-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/379ed701b937/nihms-15931-0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/451730690b78/nihms-15931-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/2c8493095214/nihms-15931-0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/b42d0c3ccc79/nihms-15931-0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65c6/1780038/8304f839b04f/nihms-15931-0008.jpg

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本文引用的文献

1
Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial.检测源自呋喃活性代谢物顺式-2-丁烯-1,4-二醛的DNA加合物。
Chem Res Toxicol. 2006 Mar;19(3):414-20. doi: 10.1021/tx050302k.
2
2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release.X射线辐照DNA中的2-脱氧核糖内酯损伤：通过催化释放5-亚甲基-2-呋喃酮进行定量测定。
Angew Chem Int Ed Engl. 2005 Sep 26;44(38):6210-3. doi: 10.1002/anie.200501956.
3
Selective detection of 2-deoxyribonolactone in DNA.
基于酶机制的、在体内与DNA聚合酶β形成的氧化性DNA-蛋白质交联。
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8602-7. doi: 10.1073/pnas.1501101112. Epub 2015 Jun 29.
4
One-electron oxidation of neutral sugar radicals of 2'-deoxyguanosine and 2'-deoxythymidine: a density functional theory (DFT) study.单电子氧化 2'-脱氧鸟嘌呤核苷和 2'-脱氧胸苷中性糖自由基：密度泛函理论（DFT）研究。
J Phys Chem B. 2012 Aug 9;116(31):9409-16. doi: 10.1021/jp3059068. Epub 2012 Jul 27.
5
Factors affecting the yields of C1' and C5' oxidation products in radiation-damaged DNA: the indirect effect.影响辐射损伤 DNA 中 C1' 和 C5' 氧化产物产率的因素：间接效应。
Radiat Res. 2010 Nov;174(5):645-9. doi: 10.1667/RR2263.1. Epub 2010 Sep 7.
6
Quantification of the 2-deoxyribonolactone and nucleoside 5'-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA.通过同位素稀释气相色谱质谱法定量测定 DNA 和细胞中 2-脱氧核糖氧化的 2-脱氧核糖内-1,2-环氧化物和核苷 5'-醛产物：γ 射线和 Fe2+-EDTA 的差异效应。
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J Am Chem Soc. 2008 May 14;130(19):6080-1. doi: 10.1021/ja801715c. Epub 2008 Apr 16.
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