一种发光的 C 类似物可区分 G、8-氧代鸟嘌呤和 T。
An emissive C analog distinguishes between G, 8-oxoG, and T.
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.
出版信息
Org Lett. 2009 Mar 5;11(5):1115-8. doi: 10.1021/ol802656n.
Abstract
A minimally disruptive fluorescent dC analog provides a rapid and non-destructive method for in vitro detection of G, 8-oxoG, and T, the downstream transverse mutation product.
摘要
一种低干扰的荧光 dC 类似物提供了一种快速、非破坏性的方法，用于体外检测 G、8-oxoG 和 T，后者是下游横向突变产物。
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本文引用的文献
1
Fluorescence and hybridization properties of peptide nucleic acid containing a substituted phenylpyrrolocytosine designed to engage Guanine with an additional H-bond.含取代苯基吡咯并胞嘧啶的肽核酸的荧光和杂交特性，该取代苯基吡咯并胞嘧啶旨在通过额外的氢键与鸟嘌呤结合。
J Am Chem Soc. 2008 Sep 24;130(38):12574-5. doi: 10.1021/ja804233g. Epub 2008 Aug 30.
2
A highly emissive fluorescent nucleoside that signals the activity of toxic ribosome-inactivating proteins.一种高发射性荧光核苷，可指示有毒核糖体失活蛋白的活性。
Angew Chem Int Ed Engl. 2008;47(35):6661-5. doi: 10.1002/anie.200802199.
3
Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against carcinogenesis.7,8-二氢-8-氧代鸟嘌呤修复系统作为抗癌发生的一道防线。
J Radiat Res. 2008 Jul;49(4):329-40. doi: 10.1269/jrr.08049. Epub 2008 Jul 3.
4
Using an emissive uridine analogue for assembling fluorescent HIV-1 TAR constructs.使用一种发射性尿苷类似物来组装荧光HIV-1 TAR构建体。
Tetrahedron. 2007 Apr 23;63(17):3601-3607. doi: 10.1016/j.tet.2007.01.074.
5
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Tetrahedron. 2007 Apr 23;63(17):3515-3527. doi: 10.1016/j.tet.2007.01.073.
6
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Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13535-6. doi: 10.1073/pnas.0706878104. Epub 2007 Aug 15.
7
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Nature. 2007 Jun 21;447(7147):941-50. doi: 10.1038/nature05978.
8
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9
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10
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