Ng Tze-Pin, Chiam Peak-Chiang, Kua Ee-Heok
Gerontological Research Programme, Faculty of Medicine, National University of Singapore, Singapore.
Int J Geriatr Psychiatry. 2007 Jul;22(7):668-74. doi: 10.1002/gps.1728.
Clinical studies have mostly linked anxiety disorders with asthma in young patients, but the data are inconsistent for depression. Few population-based studies have investigated the co-morbid diagnoses of mental disorders with asthma in older adults.
Cross-sectional study of a population sample of older adults aged 60 and above (n = 1092). The diagnoses of recent depression and anxiety were made using the Geriatric Mental State (GMS) Schedule. The presence of asthma was ascertained by self-reports of physician-diagnosed asthma.
Asthma was associated with a higher prevalence of depressive disorders, with odds ratio of 2.45 (95% CI, 1.06-5.69) when compared against non-asthmatic controls; and 2.42 (95% CI, 1.04-5.64) when compared against controls with other chronic illnesses, after adjusting for psychosocial factors, physical co-morbidity and use of depression-causing drugs. Odds ratios were elevated but statistically insignificant for anxiety disorders and dementia.
We observed that asthma in the elderly was more evidently associated co-morbidly with depression, rather than anxiety disorder. However, possible associations with anxiety and dementia are not excluded, and should be further investigated.
临床研究大多将年轻患者的焦虑症与哮喘联系起来,但关于抑郁症的数据并不一致。很少有基于人群的研究调查老年人中精神障碍与哮喘的共病诊断情况。
对1092名60岁及以上的老年人群样本进行横断面研究。使用老年精神状态(GMS)量表对近期的抑郁和焦虑进行诊断。通过医生诊断哮喘的自我报告来确定哮喘的存在。
哮喘与抑郁症的患病率较高相关,在调整社会心理因素、身体共病和使用导致抑郁的药物后,与非哮喘对照组相比,比值比为2.45(95%可信区间,1.06 - 5.69);与患有其他慢性疾病的对照组相比,比值比为2.42(95%可信区间,1.04 - 5.64)。焦虑症和痴呆症的比值比有所升高,但无统计学意义。
我们观察到老年人中的哮喘与抑郁症的共病关联更为明显,而非焦虑症。然而,不排除与焦虑症和痴呆症的可能关联,应进一步研究。