Inhibitors of the FEZ-1 metallo-beta-lactamase.
作者信息
Liénard Benoît M R, Horsfall Louise E, Galleni Moreno, Frère Jean-Marie, Schofield Christopher J
机构信息
Chemistry Research Laboratory, 12 Mansfield Road, Oxford, United Kingdom.
出版信息
Bioorg Med Chem Lett. 2007 Feb 15;17(4):964-8. doi: 10.1016/j.bmcl.2006.11.053. Epub 2006 Nov 18.
PMID:17157014
Abstract
Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of 6.1+/-0.7microM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.
摘要
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