希腊年龄相关性黄斑变性的患病率：塞萨洛尼基眼病研究

Prevalence of age-related macular degeneration in Greece: the Thessaloniki Eye Study.

作者信息

Topouzis Fotis, Coleman Anne L, Harris Alon, Anastasopoulos Eleftherios, Yu Fei, Koskosas Archimidis, Pappas Theofanis, Mavroudis Leonidas, Wilson M Roy

机构信息

II Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

出版信息

Am J Ophthalmol. 2006 Dec;142(6):1076-9. doi: 10.1016/j.ajo.2006.07.042. Epub 2006 Sep 5.

DOI:10.1016/j.ajo.2006.07.042

PMID:17157601

Abstract

PURPOSE

To estimate the age- and gender-specific prevalence of age-related macular degeneration (AMD) in a population-based sample of subjects 60 years of age or older in Thessaloniki, Greece.

DESIGN

Cross-sectional population-based study.

METHODS

A total of 2554 subjects randomly identified from municipality registers in Thessaloniki underwent a complete ophthalmologic examination.

RESULTS

Of the 3617 eligible subjects, 2554 (71%) participants completed a clinical examination. The prevalence was 2.5% for AMD, 1.4% for neovascular (NV) AMD, and 1.3% for geographic atrophy (GA). Bilateral AMD was present in 40% of AMD cases. The prevalence of AMD, NV, GA, and bilateral AMD increased with increasing age (P< .0001). No gender-specific statistically significant differences were noted. Of all participants with AMD, 67% were unaware of the diagnosis.

CONCLUSIONS

The prevalence of AMD in Greece is comparable to that in other Caucasian populations. A dramatic increase in prevalence in people older than 80 years of age was observed.

摘要

目的

在希腊塞萨洛尼基以人群为基础的60岁及以上受试者样本中，评估年龄相关性黄斑变性（AMD）的年龄和性别特异性患病率。

设计

基于人群的横断面研究。

方法

从塞萨洛尼基市登记册中随机抽取的2554名受试者接受了全面的眼科检查。

结果

在3617名符合条件的受试者中，2554名（71%）参与者完成了临床检查。AMD的患病率为2.5%，新生血管性（NV）AMD为1.4%，地图样萎缩（GA）为1.3%。40%的AMD病例存在双侧AMD。AMD、NV、GA和双侧AMD的患病率随年龄增长而增加（P<0.0001）。未发现性别特异性的统计学显著差异。在所有患有AMD的参与者中，67%未意识到自己的诊断。